Physiology-based model of cell viscoelasticity.
نویسندگان
چکیده
The measured viscoelastic properties of biological tissues is the result of the passive and active response of the cells. We propose an evolution law of the remodeling process in the cytoskeleton which is able to mimic the viscous properties of biological cellular tissues. Our model is based on dynamical changes of the resting length. We show that under the small strain regime, the linear rheology models are recovered, with the relaxation time being replaced by the cell resistance to remodel. We implement the one-dimensional model into network systems of two and three dimensions, and show that the same conclusions may be drawn for those systems.
منابع مشابه
Effects of Surface Viscoelasticity on Cellular Responses of Endothelial Cells
Background: One area of nanoscience deals with nanoscopic interactions between nanostructured materials and biological systems. To elucidate the effects of the substrate surface morphology and viscoelasticity on cell proliferation, fractal analysis was performed on endothelial cells cultured on nanocomposite samples based on silicone rubber (SR) and various concentrations of organomodified nano...
متن کاملAn Exact Solution for Kelvin-Voigt Model Classic Coupled Thermo Viscoelasticity in Spherical Coordinates
In this paper, the classic Kelvin-Voigt model coupled thermo-viscoelasticity model of hollow and solid spheres under radial symmetric loading condition is considered. A full analytical method is used and an exact unique solution of the classic coupled equations is presented. The thermal and mechanical boundary conditions, the body force, and the heat source are considered in the most general fo...
متن کاملDynamic Coupled Thermo-Viscoelasticity of a Spherical Hollow Domain
The generalized coupled thermo-viscoelasticity of hollow sphere subjected to thermal symmetric shock load is presented in this paper. To overcome the infinite speed of thermal wave propagation, the Lord-Shulman theory is considered. Two coupled equations, namely, the radial equation of motion and the energy equation of a hollow sphere are obtained in dimensionless form. Resulting equations are ...
متن کاملViscoelasticity reduces the dynamic stresses and strains in the vessel wall: implications for vessel fatigue.
The mechanical behavior of blood vessels is known to be viscoelastic rather than elastic. The functional role of viscoelasticity, however, has remained largely unclear. The hypothesis of this study is that viscoelasticity reduces the stresses and strains in the vessel wall, which may have a significant impact on the fatigue life of the blood vessel wall. To verify the hypothesis, the pulsatile ...
متن کاملThermo-mechanical analysis of diesel engines cylinder heads using a two-layer viscoelasticity model with considering viscosity effects
Loading conditions and complex geometry have led the cylinder heads to become the most challenging parts of diesel engines. One of the most important durability problems in diesel engines is due to the cracks valves bridge area. The purpose of this study is a thermo-mechanical analysis of cylinder heads of diesel engines using a two-layer viscoelasticity model. The results of the thermo-mechani...
متن کاملE-wave deceleration time may not provide an accurate determination of LV chamber stiffness if LV relaxation/viscoelasticity is unknown.
Average left ventricular (LV) chamber stiffness (Delta P(avg)/Delta V(avg)) is an important diastolic function index. An E-wave-based determination of Delta P(avg)/Delta V(avg) (Little WC, Ohno M, Kitzman DW, Thomas JD, Cheng CP. Circulation 92: 1933-1939, 1995) predicted that deceleration time (DT) determines stiffness as follows: Delta P(avg)/Delta V(avg) = N(pi/DT)(2) (where N is constant), ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Physical review. E, Statistical, nonlinear, and soft matter physics
دوره 88 1 شماره
صفحات -
تاریخ انتشار 2013